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Protein G

Protein G is an immunoglobulin-binding protein expressed in group C and G Streptococcal bacteria much like Protein A but with differing specificities. It is a 65-kDa (G148 protein G) and a 58 kDa (C40 protein G)[1] cell surface protein that has found application in purifying antibodies through its binding to the Fc region. The native molecule also binds albumin, however, because serum albumin is a major contaminant of antibody sources, the albumin binding site has been removed from recombinant forms of Protein G.

Other antibody binding proteins

In addition to Protein G, other immunoglobulin-binding bacterial proteins such as Protein A, Protein A/G and Protein L are all commonly used to purify, immobilize or detect immunoglobulins. Each of these immunoglobulin-binding proteins has a different antibody binding profile in terms of the portion of the antibody that is recognized and the species and type of antibodies it will bind.


  1. ^ 1 Sjobring U, Bjorck L, Kastern W, Streptococcal protein G. Gene structure and protein binding properties, J Biol Chem. 1991 Jan 5;266(1):399-405
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Protein_G". A list of authors is available in Wikipedia.
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