My watch list
my.chemeurope.com  
Login  

Prothrombinase



Prothrombinase is the protein complex which consist of negatively charged phospholipid (phosphatidylserine), prothrombin, Va and Xa. The prothrombinase complex converts prothrombin, an inactive protease, into thrombin which has proteolytic activity.

Additional recommended knowledge

Assembly of the prothrombinase complex occurs on activated platelets. In normal conditions platelets do not expose negatively charged phospholipids on the surface. However binding to collagen sets a sequence of biochemical reactions in motion that activate the membrane protein scramblase. Scramblase transports negatively charged phospholipids from the inner leaflet of the membrane to the outer leaflet. The presence of negatively charged phospholipids allows the binding and the formation of the prothrombinase complex.


See also

hemostasis

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Prothrombinase". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE