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Punicic acid

Punicic acid
Chemical name 9Z,11E,13Z-octadeca-9,11,13-trienoic acid
Chemical formula C18H30O2
Molecular mass 278.43 g/mol
Melting point 44-45 °C
PubChem 5281126
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Punicic acid (also called trichosanic acid) is a polyunsaturated fatty acid, 18:3 (n-5). It is named for the pomegranate, (Punica granatum), and is obtained from pomegranate seed oil. It is also found in the seed oils of snake gourd and bitter gourd.[1]

Punicic acid is a conjugated linolenic acid or ClnA; i.e. it has three conjugated double bonds. It is chemically similar to the conjugated linoleic acids, or CLA, which have two. In lab rats, it was found that punicic acid was converted to the CLA rumenic acid (9Z11E-CLA).[2] In vitro, it shows anticancer activity against prostate cancer cells.[3] OLETF rats—a strain which becomes obese—remained relatively lean when punicic acid was added to their feed.[4] Fat cells undergo programmed cell death when exposed to punicic acid from bitter-gourd oil.[5]

See also


  1. ^ Cyberlipid. POLYENOIC FATTY ACIDS. Retrieved on 2007-01-11.
  2. ^ Tsuzuki T, Kawakami Y, Abe R (Aug 2006). "Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid". J Nutr 136 (8): 2153-9. Retrieved on 2007-01-23.
  3. ^ Lansky E, Harrison G, Froom P, Jiang W (2005). "Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel". Invest New Drugs 23 (2): 121-2. PMID 15744587. Retrieved on 2007-01-23.
  4. ^ Arao K, Wang Y, Inoue N, Hirata J, Cha J, Nagao K, Yanagita T. "Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF rats". Lipids Health Dis 3: 24. PMID 15533261. Retrieved on 2007-01-23.
  5. ^ Nishimura K, Tsumagari H, Morioka A, Yamauchi Y, Miyashita K, Lu S, Jisaka M, Nagaya T, Yokota K. "Regulation of apoptosis through arachidonate cascade in mammalian cells". Appl Biochem Biotechnol 102-103 (1-6): 239-50. PMID 12396127. Retrieved on 2007-01-29.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Punicic_acid". A list of authors is available in Wikipedia.
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