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The rank product is a biologically motivated test for the detection of differentially expressed genes in replicated microarray experiments. It is a simple non-parametric statistical method based on ranks of fold changes. In addition to its use in expression profiling, it can be used to combine ranked lists in various application domains, including proteomics, metabolomics, statistical meta-analysis, and general feature selection.
Additional recommended knowledge
Calculation of the rank product
Given n genes and k replicates, let eg,i be the fold change and rg,i the rank of gene g in the i-th replicate.
Compute the rank product via the geometric mean:
Determination of significance levels
Simple permutation-based estimation is used to determine how likely a given RP value or better is observed in a random experiment.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rank_product". A list of authors is available in Wikipedia.|