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Rebeccamycin is a weak topoisomerase I inhibitor isolated from Streptomyces sp. structurally similar to staurosporine. Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rebeccamycin". A list of authors is available in Wikipedia.|