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Ropinirole



Ropinirole
Systematic (IUPAC) name
4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one
Identifiers
CAS number 91374-21-9
ATC code N04BC04
PubChem 5095
DrugBank APRD00302
Chemical data
Formula C16H24N2O 
Mol. mass 260.375 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 6 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C

Legal status

Prescription only

Routes Oral

Ropinirole (marketed as Requip®) is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson's disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole).

Additional recommended knowledge

Dosing

Requip (it is marketed as Adartrel in Europe for the Restless Legs Syndrome indication and as Requip for the anti-Parkinson indication) is available in various preparations, ranging from the .25 mg tablet to the 5 mg tablet. The primary reason for such is dose titration. This implies that the person taking ReQuip has to closely interact and communicate with the Primary Care Physician with regard to how much should actually be taken by the patient.

For Restless Legs Syndrome or RLS, the maximum recommended dose is 4 mg per day, taken 1 to 3 hours before bedtime.

For Parkinson's Disease or PD, the maximum recommended dose is 24 mg per day, taken in three separate doses spread throughout the day.

Mechanism

Ropinirole acts as an agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, α1-, α2-, and β-adrenoreceptors.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ropinirole". A list of authors is available in Wikipedia.
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