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The Rubottom oxidation is the chemical reaction of enolsilanes with m-chloroperoxybenzoic acid to give silyl-protected α-hydroxy ketones.
Additional recommended knowledge
Oxidation of the enolsilane (1) with m-chloroperoxybenzoic acid initially gives an epoxysilane (2). Rearrangement through a zwitterionic intermediate (3) gives the desired α-hydroxy ketone (4).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Rubottom_oxidation". A list of authors is available in Wikipedia.|