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Small Temporal RNA or stRNA regulate gene expression during worm development by preventing the mRNAs they bind to being translated[1]

In contrast to siRNA downregulate expression of target RNAs after translation initiation without affecting mRNA stability[1].

stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of their target genes. stRNAs are transcribed as longer precursor RNAs that are processed by the RNase Dicer/DCR-1 and members of the RDE-1/AGO1 family of proteins, which are better known for their roles in RNA interference (RNAi). stRNAs may function to control temporal identity during development in C. elegans and other organisms[1]



This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "StRNA". A list of authors is available in Wikipedia.
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