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Strabismus (protein)
Strabismus was originally identified as a Drosophila protein involved in planar cell polarity [1]. Flies with mutated stranismus genes have altered development of omatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh"). Product highlightThe amino acid sequence and localization studies for Strabismus indicate that it is a membran protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus[2]. In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells[3]. Vertebrate cell movement
VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis[4]. References
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| This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Strabismus_(protein)". A list of authors is available in Wikipedia. | ||||||||||||||||||||
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