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Transcript of unknown function
Transcripts of unknown function (TUFs) is the name that has been suggested for known RNA transcripts of DNA whose function is unclear. Most TUFs are probably ncRNAs, such as RNAi or snoRNAs, but could also represent a whole new class of ncRNA. The DNA sequences for TUFs reside in the intergenic or intronic regions of the genome, which is often called junk DNA. This currently makes up much of the human genome, although the percentage of the genome that falls under the TUFs category is likely to go down significantly as more progress is made towards understanding the many roles of RNA.
Additional recommended knowledge
Categories of TUFs
Broadly speaking, TUFs can be classified into three categories:
There are very few details known about TUFs, which is why the phrase even exists, but one thing that has been shown several times is that they are not very conserved between mice and humans. This could be due to a number of factors, including more recent evolution in the primate lineage or extensive post-transcriptional modification of the RNA.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Transcript_of_unknown_function". A list of authors is available in Wikipedia.|