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Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.
Additional recommended knowledge
In addition, Triacsin C is a potent vasodilator.
General chemical description
Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus. Due to the N-hydroxytriazene group, Triacsin C has acidic properties and may be considered a polyunsaturated fatty acid analog.
Triacsin C was discovered by Yoshida K, and other Japanese scientists, in 1982, in a culture of the microbe Streptomyces aureofaciens. They identified it as a vasodilator.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Triacsin_C". A list of authors is available in Wikipedia.|