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Tunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis. This blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase. It is used as an experimental tool in biology. Tunicamycin is produced by the bacterium Streptomyces Iysosuperficus.

See also

  • Glycosylation - tunicamycin blocks all N-glycosylation of proteins
  • Glycoprotein
  • Streptomyces the genus
  • the species Streptomyces clavuligerus produces a related molecule

External links

  • book section of Essentials in Glycobiology (1999) Tunicamycin: Inhibition of DOL-PP-GlcNAc Assembly
  • Tunicamycin data sheet prepared by a student of the Open University, UK
  • Tunicamycin product details of the company USBiologicals
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Tunicamycin". A list of authors is available in Wikipedia.
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