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Vicarious nucleophilic substitution
Vicarious nucleophilic substitution in organic chemistry is a special type of nucleophilic aromatic substitution in which a nucleophile replaces hydrogen and not an aromatic substituent like a halogen that is ordinarily encountered in this reaction type. This reaction type was introduce in 1987 by Mieczyslaw Makosza and Jerzy Winiarski.
Additional recommended knowledge
It is typically encountered with nitroarenes and especially with carbon nucleophiles, resulting in new alkylated arenes. Carbon nucleophiles carry a electron-withdrawing group and a nucleofuge:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Vicarious_nucleophilic_substitution". A list of authors is available in Wikipedia.|