To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
The Wieland-Miescher ketone  is a bicyclic di-ketone (enedione) and is a versatile synthon which has so far been employed in the total synthesis of more than 50 natural products, predominantly sesquiterpenoids, diterpenes and steroids possessing exceptionally promising biological properties including anticancer, antimicrobial, antiviral, antineurodegenerative and immunomodulatory activities. Examples of syntheses performed using this ketone as a starting material are that of ancistrofuran  and in the Danishefsky Taxol total synthesis. Most advances in total synthesis methods starting from Wieland-Miescher ketone were fueled by the search for alternative methods for the industrial synthesis of contraceptive and other medicinally relevant steroids, an area of research that flourished in the 1960s and 1970s. Wieland-Miescher ketone contains the AB-ring structure of steroids and is for this reason an attractive starting material toward the steroid skeleton, an approach used in one successful synthesis of adrenosterone.
Additional recommended knowledge
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Wieland-Miescher_ketone". A list of authors is available in Wikipedia.|