My watch list  

Wolff-Chaikoff effect

Wolff-Chaikoff effect is used to describe hypothyroidism caused by ingestion of a large amount of iodine.[1]

It is an autoregulatory phenomenon which inhibits formation of thyroid hormones inside of the thyroid follicle. This becomes evident secondary to elevated levels of circulating iodide. Wolff-Chaikoff effect lasts several days, after which it is followed by an "escape phenomenon",[2] which is described by resumption of normal organification of iodine and normal thyroid peroxidase function. "Escape phenomenon" is believed to occur because of decreased inorganic iodine concentration secondary to down-regulation of sodium-iodide symporter on the basolateral membrane of the Thyroid Follicular cell.

Wolff-Chaikoff effect can be used as a treatment principle against thyroid storm by infusion a large amount of iodine to shut down the hyperfunctioning thyroid gland, or an unpleasant iatrogenic effect of several iodine containing drugs, of which the most famous is amiodarone.

Jodbasedow effect is iodine-induced hyperthyroidism.


  1. ^ Physiology at MCG 5/5ch5/s5ch5_6
  2. ^ Eng P, Cardona G, Fang S, Previti M, Alex S, Carrasco N, Chin W, Braverman L (1999). "Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein". Endocrinology 140 (8): 3404-10. PMID 10433193.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Wolff-Chaikoff_effect". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE