Combinatorial Chemistry

Products Combinatorial Chemistry

Focused Microwave Synthesis with CEM Systems

The Discover line of microwave synthesis systems is built upon CEM's Focused™ Microwave Technology designed to automatically focus microwave energy with maximum efficiency to the reaction more

Sterile plates enhance cellular growth applications

BactiGrowth plates from Porvair Sciences Ltd. offer a contamination free deep-well microplate optimised for high yield growth of bacteria, yeast and more

Liberty Microwave-Enhanced Peptide Synthesis

Microwave peptide synthesis is a well-accepted technology that has been cited in over 300 publications. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis more

Videos Combinatorial Chemistry

Liberty Microwave-Enhanced Peptide Synthesis

Over the past several years, chemists have been using microwave energy to conduct a multitude of organic reactions with transformations taking place in a matter of minutes compared to hours with traditional methods. Now for the first time, microwave synthesis has been applied to the complete proces more

Focused Microwave Synthesis with CEM Systems

Single-mode cavity design At the heart of the new Discover System resides the technology which makes it so unique. The patented circular single-mode cavity design directs the microwave energy into a defined area, resulting in a homogenous field pattern surrounding the sample. "Focusing" the microwav more

News Combinatorial Chemistry

• AMRI Names New Chemistry Director at Its European Site

  AMRI has named Dr. Philip William Small as director of chemistry at its Hungarian site. In his new position, Dr. Small will assume responsibilities for all of AMRI's European chemistry related activities including custom synthesis, medicinal chemistry, analytical services, library design and product more

• ChemDiv to Supply Italien Nerviano Medical Sciences with Discovery Chemical Libraries

  ChemDiv, Inc. and Nerviano Medical Sciences (NervianoMS), Milano, Italy, announced an extension of their collaboration to an additional 2 year program. NervianoMS will use services of ChemDiv for building and enriching its portfolio of proprietary discovery chemical libraries. Such compound librarie more

• Electric field provides stimulus: chemical system responds by forming liquid crystals

  Jean-Marie Lehn, winner of the Nobel Prize in chemistry (1987) and his co-worker Nicolas Giuseppone have now demonstrated that an electric field induces the preferred formation of liquid-crystalline imines. They started with batches of amines (organic compounds with a nitrogen- and hydrogen-contain more

Publications Combinatorial Chemistry

• CROSS: An Efficient Workflow for Reaction-Driven Rescaffolding and Side-Chain Optimization Using Robust Chemical Reactions and Available Reagents

  A novel procedure (CROSS: Computational Rescaffolding and Optimization using Synthetic Schemes) for in silico rescaffolding and side-chain optimization is reported with explicit consideration of the route of synthesis and availability of compatible chemical reagents. We have defined a set of retrosy more

• A Synthetic Receptor for Asymmetric Dimethyl Arginine

  Dynamic combinatorial chemistry was utilized to identify a novel small molecule receptor, A2D, for asymmetric dimethyl arginine (aRMe2), which is a post-translational modification (PTM) in proteins. It is known to play a role in a number of diseases, including spinal muscular atrophy, leukemia, lymp more

• Glycosynthase with Broad Substrate Specificity – an Efficient Biocatalyst for the Construction of Oligosaccharide Library

  Abstract A versatile glycosynthase (TnG‐E338A) with strikingly broad substrate scope has been developed from Thermus nonproteolyticus β‐glycosidase (TnG) by using site‐directed mutagenesis. The practical utility of this biocatalyst has been demonstrated by the facile generation of a small librar more

Websites Combinatorial Chemistry