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Ketal



 

Additional recommended knowledge

A ketal is a functional group or molecule containing the functional group of a carbon bonded to two -OR groups, where O is oxygen and R represents any alkyl group. It is essentially equivalent to an acetal, and often the term acetal is used instead. The difference derives from the reaction which created the molecule. Acetals traditionally derive from the product of the reaction of an aldehyde with excess of alcohol, whereas the name ketal derives from the product of the reaction of a ketone with excess alcohol. Although this term had been abandoned, it has been reinstated by IUPAC as a subclass of acetals. Ketals have the general form shown on the right, where R, R', R'', and R''' are carbon backbones. If R = H, the structure is a traditional acetal.

Ketals and acetals can be used as carbonyl-protecting groups.

Reactions

Synthesis

Although there are plenty ways to synthesize a ketal, they are generally made using an alcohol an acid catalysis and any way to remove water from the reaction (e.g. a Dean-Stark apparatus), driving the equilibrium of the reaction to the completion.

Ketals and acetals can, under acidic conditions, be converted back into a hemiacetal and an alcohol, as the entire reaction is an equilibrium.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ketal". A list of authors is available in Wikipedia.
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