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Monobenzone


Monobenzone
Systematic (IUPAC) name
4-(Benzyloxy}phenol
Identifiers
CAS number	103-16-2
ATC code	D11AX13
PubChem	?
Chemical data
Formula	C₁₃H₁₂O₂
Mol. mass	200.233 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Topical

Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water.

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Pharmacology

The topical application of monobenzone in animals increases the excretion of melanin from the melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.

The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo; the epidermis is normal except for the absence of identifiable melanocytes. Therefore, monobenzone is used as a topical medicine to permanently depigment normal skin surrounding vitiliginous lesions only in patients with disseminated (greater than 50 percent of body surface area) idiopathic vitiligo.

Sources

http://www.chemicalland21.com/lifescience/foco/BENOQUIN.htm
http://www.medicinenet.com/monobenzone-topical/article.htm

v • d • e Other dermatological preparations (D11)
Medicated shampoos	Cetrimide - Cadmium compounds - Selenium compounds - Povidone-iodine - Sulfur compounds - Xenysalate
Other dermatologicals	seborrhoeic dermatitis/dandruff (Lithium succinate, Pyrithione zinc) - skin whitening/depigmenting (Hydroquinone, Mequinol, Monobenzone) - anti-inflammatory/Immunomodulators (Oxaceprol, Gamolenic acid), Pimecrolimus, Tacrolimus) - baldness treatments (Finasteride, Minoxidil) - hair growth inhibiting agent (Eflornithine) - other (Calcium gluconate, Magnesium sulfate, Tiratricol)