Relaxation (NMR)

In nuclear magnetic resonance (NMR) spectroscopy and magnetic resonance imaging (MRI) the term relaxation describes several processes by which nuclear magnetization prepared in a non-equilibrium state return to the equilibrium distribution. In other words, relaxation describes how fast spins "forget" the direction in which they are oriented. The rates of this spin relaxation can be measured in both spectroscopy and imaging applications.

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T₁ and T₂

Different physical processes are responsible for the relaxation of the components of the nuclear spin magnetization vector M parallel perpendicular to the external magnetic field, B₀ (which is conventionally oriented along the z axis). These two principal relaxation processes are termed T₁ and T₂ relaxation respectively.

T₁

Main article: Spin-lattice relaxation time

The longitudinal relaxation time T₁ is the decay constant for the recovery of the z component of the nuclear spin magnetization, M_z, towards its thermal equilibrium value, M_z,eq. In general,

In specific cases:

• If M has been tilted into the xy plane, then M_z(0) = 0 and the recovery is simply

i.e. the magnetisation recovers to 63% of its equilibrium value after one time constant T₁.

• In the inversion recovery experiment, commonly used to measure T₁ values, the initial magnetisation is inverted, M_z(0) = − M_z,eq, and so the recovery follows

T₁ relaxation involves redistributing the populations of the nuclear spin states in order to reach the thermal equilibrium distribution. By definition this is not energy conserving. Moreover, spontaneous emission is negligibly slow at NMR frequencies. Hence truly isolated nuclear spins would show negligible rates of T₁ relaxation. However, a variety of relaxation mechanisms allow nuclear spins to exchange energy with their surroundings, the lattice, allowing the spin populations to equilibrate. The fact that T₁ relaxation involves an interaction with the surroundings is the origin of the alternative description, spin-lattice relaxation.

Note that the rates of T₁ relaxation are generally strongly dependent on the NMR frequency and so may vary considerably with magnetic field strength, B.

T₂

Main article: Spin-spin relaxation time

The transverse relaxation time T₂ is the decay constant for the component of M perpendicular to B₀, designated M_xy, M_T, or . For instance, initial xy magnetisation at time zero will decay to zero (i.e. equilibrium) as follows:

i.e. the transverse magnetization vector drops to 37% of its original magnitude after one time constant T₂.

T₂ relaxation is a complex phenomenon, but at its most fundamental level, it corresponds to a decoherence of the transverse nuclear spin magnetization. Random fluctuations of the local magnetic field lead to random variations in the instantaneous NMR precession frequency of different spins. As a result, the intial phase coherence of the nuclear spins is lost, until eventually the phases are disordered and there is no net xy magnetization. Because T₂ relaxation involves only the phases of other nuclear spins it is often called "spin-spin" relaxation.

T₂ values are generally much less dependent on field strength, B, than T₁ values.

T₂* and magnetic field inhomogeneity

In an idealized system, all nuclei in a given chemical environment in a magnetic field spin with the same frequency. However, in real systems, there are minor differences in chemical environment which can lead to a distribution of resonance frequencies around the ideal. Over time, this distribution can lead to a dispersion of the tight distribution of magnetic spin vectors, and loss of signal (Free Induction Decay). In fact, for most magnetic resonance experiments, this "relaxation" dominates. This results in intra-voxel dephasing.

However, decoherence because of magnetic field inhomogeneity is not a true "relaxation" process; it is not random, but dependent on the location of the molecule in the magnet. For molecules that aren't moving, the deviation from ideal relaxation is consistent over time, and the signal can be recovered by performing a spin echo experiment.

The corresponding transverse relaxation time constant is thus T₂^*, which is usually much smaller than T₂. The relation between them is:

where γ represents gyromagnetic ratio, and ΔB₀ the difference in strength of the locally varying field.

Unlike T₂, T₂* is influenced by magnetic field gradient irregularities. The T₂* relaxation time is always shorter than the T₂ relaxation time and is typically milliseconds for water samples in imaging magnets.

The reason that T₁ is slower than T₂

As a general rule, the following always holds true: T₁ > T₂ > T₂*.

If T₂ were to be slower than T₁, then the magnetizations perpendicular to the initial direction would have not dephased by the time the sample had returned to equilibrium. This is physically impossible, as once the sample has returned to equilibrium, there is no magnetization perpendicular to the original direction. Hence, T₁ must be greater than or equal to T₂.

Common relaxation time constants in human tissues

Following is a table of the approximate values of the two relaxation time constants for nonpathological human tissues, just for simple reference.

Following is a table of the approximate values of the two relaxation time constants for chemicals that commonly show up in human brain magnetic resonance spectroscopy (MRS) studies, physiologically or pathologically.

Microscopic mechanism

In 1948, Nicolaas Bloembergen, Edward Mills Purcell, and R.V. Pound proposed the so-called Bloembergen-Purcell-Pound theory (BPP theory) to explain the relaxation constant of a pure substance in correspondence with its state, taking into account the effect of tumbling motion of molecules on the local magnetic field disturbance ^[4]. The theory was in good agreement with the experiments for pure substance, but not for complicated environment such as human body.

From this theory, one can get T₁、T₂:

,

where ω₀ is the Larmor frequency in correspondence with the strength of the main magnetic field B₀. τ_c is the correlation time of the molecular tumbling motion. is a constant with μ being the magnetic dipole moment of the spin-1/2 nuclei, the reduced Planck constant, γ the gyromagnetic ratio of such species of nuclei, and r the distance between the two nuclei carrying magnetic dipole moment.

Taking for example the H₂O molecules in liquid phase without the contamination of oxygen 17, the value of K is 1.02×10¹⁰ s^-2 and the correlation time τ_c is on the order of picoseconds = 10 ^{− 12} s, while hydrogen nuclei ¹H (protons) at 1.5 teslas carry an Larmor frequency of approximately 64 MHz. We can then estimate using τ_c = 5×10^-12 s:

(dimensionless)

= 3.92 s

= 3.92 s,

which is close to the experimental value, 3.6 s. Meanwhile, we can see that at this extreme case, T₁ equals T₂.

References

1. ^  Chemicals of brain relaxation time at 1.5T. Kreis R, Ernst T, and Ross BD "Absolute Quantification of Water and Metabolites in the Human Brain. II. Metabolite Concentrations" Journal of Magnetic Resonance, Series B 102 (1993): 9-19
2. ^  Lactate relaxation time at 1.5 T. Isobe T, Matsumura A, Anno I, Kawamura H, Muraishi H, Umeda T, Nose T. "Effect of J coupling and T2 Relaxation in Assessing of Methyl Lactate Signal using PRESS Sequence MR Spectroscopy." Igaku Butsuri (2005) v25. 2:68-74.
3. ^  BPP theory. Bloembergen, E.M. Purcell, R.V. Pound "Relaxation Effects in Nuclear Magnetic Resonance Absorption" Physical Review (1948) v73. 7:679-746

See also

• MRI - Magnetic resonance imaging Animation made by bigs.eu; contents are: spin, spin modification, induction, relaxation and precession, spin echo sequence, gradient echo sequence, inversion recovery sequence
• [5] Relaxation in high-resolution NMR spectroscopy
• Relaxometry