My watch list
my.chemeurope.com  
Login  

By-product of Teflon manufacture used to generate compounds for medicinal, agrichemical and materials sciences

31-Jan-2013

Scientists in Japan have used a by-product of Teflon manufacture to generate carbonyl compounds with trifluoromethyl groups. Organic molecules bearing a trifluoromethyl group have received much attention because of their unique physical and chemical properties, which are important in the fields of medicinal, agrichemical and materials sciences, say the researchers.

Efficient ways of introducing CF3 groups into target molecules are being sought. The nucleophilic trifluoromethylation of carbonyl compounds using a Ruppert–Prakash reagent – (trifluoromethyl)trimethylsilane – is a well-explored strategy. But, (trifluoromethyl)trimethylsilane is expensive to prepare and is prepared from ozone-depleting bromotrifluoromethane. Fluoroform – a by-product of Teflon manufacture – has emerged as a potential environmentally benign alternative to (trifluoromethyl) trimethylsilane. It is also non-toxic, cheap and available in large quantities.  

Facts, background information, dossiers
  • Trifluoromethylation
  • Teflon
  • Fluoroform
  • bromotrifluoromethane
  • Nagoya University
  • (trifluoromethyl)tr…
More about Nagoya University
  • News

    'Helix-to-Tube,' a simple strategy to synthesize covalent organic nanotubes

    Kaho Maeda, Dr. Hideto Ito, Professor Kenichiro Itami of the JST-ERATO Itami Molecular Nanocarbon Project and the Institute of Transformative Bio-Molecules (ITbM) of Nagoya University, and their colleagues have reported on the development of a new and simple strategy, "helix-to-tube" to syn ... more

    Aromatic couple makes new chemical bonds

    Esters have been identified to act as a new and clean coupling partner for the carbon-carbon bond forming cross-coupling reaction to make useful compounds for pharmaceuticals, agrochemicals and organic materials. In a new collaborative study published online in Nature Communications, synthe ... more

    'Parachuting' boron on benzene rings

    Tuning the para position of benzene moieties is significant for creating biologically active compounds and optoelectronic materials. Yet, attaching a functional handle specifically at the para position of benzene has been challenging due to multiple reactive sites on the ring. Chemists at I ... more

More about RSC Publishing
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE