My watch list
my.chemeurope.com  
Login  

Toward a safer form of acetaminophen

12-Jul-2013

Efforts to develop a safer form of acetaminophen — the pain and fever-reducer that is one of the most widely used drugs — have led to discovery of substances that may have less potentially toxic effects on the liver. A report on the research appears in ACS Medicinal Chemistry Letters.

Roman Shchepin and colleagues explain that a link exists between acetaminophen and liver damage. The damage may be severe and can occur with intentional and accidental overdoses, as well as when susceptible individuals take the drug. Indeed, acetaminophen has been implicated in almost 50 percent of all acute liver failure cases in the United States alone. Scientists have known the biochemical basis of acetaminophen's liver toxicity, and Shchepin and colleagues set out to develop safer versions of acetaminophen.

They describe the design and testing of two compounds that have a similar architecture to acetaminophen, but aren't toxic to liver cells grown in the laboratory. The researchers say that, although further testing is needed, these compounds are promising candidates for acetaminophen replacements.

Facts, background information, dossiers
More about American Chemical Society
  • News

    Pulling iron out of waste printer toner

    Someday, left-over toner in discarded printer cartridges could have a second life as bridge or building components instead of as trash, wasting away in landfills and potentially harming the environment. One group reports that they have devised a method to recycle the residual powder in "emp ... more

    On the road to fire-free, lithium-ion batteries made with asphalt

    Lithium-ion batteries can be found in everything from cell phones to hoverboards, but these power sources have recently made headlines for the fires they have inadvertently caused. To address these safety hazards, scientists report that they are paving the way to better batteries with a nat ... more

    New sensors could enable more affordable detection of pollution and diseases

    When it comes to testing for cancer, environmental pollution and food contaminants, traditional sensors can help. The challenges are that they often are bulky, expensive, non-intuitive and complicated. Now, one team reports in ACS Sensors that portable pressure-based detectors coupled with ... more

  • Videos

    Why is Olive Oil Awesome?

    Whether you sop it up with bread or use it to boost your cooking, olive oil is awesome. But a lot of chemistry goes on in that bottle that can make or break a product. Take the “extra virgin” standard: Chemistry tells us that a higher free-fatty-acid content leads to a lower grade, less tas ... more

    Microbots zoom around water, destroying bacteria

    One day, the tiny robot you see here could help clean up contaminated water. In places where potable sources are scarce, they can destroy disease-causing bacteria in its path and unlike conventional disinfectants, the microbots can be removed easily with a magnet. more

    The chemicals we leave behind

    The products we use every day leave behind chemical footprints. Learn how and why researchers are now studying those trails. Mass spectrometry is helping researchers learn more about our interactions with the everyday chemicals we use, such as DEET, caffeine, even medications. In this episo ... more

  • Events
    Conference
    22-08 – 26-08
    2021
    Boston, US

    262nd ACS National Meeting & Exposition

    The American Chemical Society conference 262nd ACS National Meeting & Exposition will take place in Boston, US from 2021-08-22 to 2021-08-26. more

    Conference
    21-03 – 25-03
    2021
    San Antonio, US

    261st ACS National Meeting & Exposition

    The American Chemical Society conference 261st ACS National Meeting & Exposition will take place in San Antonio, US from 2021-03-21 to 2021-03-25. more

    Conference
    23-08 – 27-08
    2020
    San Francisco, US

    260th ACS National Meeting & Exposition

    The American Chemical Society conference 260th ACS National Meeting & Exposition will take place in San Francisco, US from 2020-08-23 to 2020-08-27. more

Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE