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2-Methyl-2-nitrosopropane (MNP or t-nitrosobutane, chemical formula (CH3)3CNO) is a spin trap. This molecule forms adducts with unstable free radicals to form a more stable paramagnetic nitroxide radical that can be detected by electron spin resonance spectroscopy. It is particularly useful for trapping carbon-centered tyrosyl radicals.
Additional recommended knowledge
MNP is also the aerial oxidation product of t-butylhydroxylamine (NtBHA), which in turn is a hydrolysis product of phenylbutylnitrone and similar spintraps. MNP has pharmacological action, both by scavenging free radicals and possibly by releasing the messenger substance nitric oxide in the presence of light and under oxidizing conditions. Production of NtHBA and its parent spintrap MNP may account for the sometime antistroke action of the drug NXY-059.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-Methyl-2-nitrosopropane". A list of authors is available in Wikipedia.|