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2-hydroxyphytanoyl-CoA lyase

2-hydroxyacyl-CoA lyase 1
Symbol HACL1
Alt. Symbols HPCL
Entrez 26061
HUGO 17856
OMIM 604300
RefSeq NM_012260
UniProt Q9UJ83
Other data
Locus Chr. 3 p24.3

2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid. It requires thiamine diphosphate (ThDP) as cofactor.[1]

It is classified under EC number 4.1.


  1. ^ Foulon V, Antonenkov V, Croes K et al. (1999). "Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acids". Proc. Natl. Acad. Sci. U.S.A. 96 (18): 10039-44. PMID 10468558.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "2-hydroxyphytanoyl-CoA_lyase". A list of authors is available in Wikipedia.
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