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Activin receptor type 1B
Other names: ACTR-IB, Serine/threonine-protein kinase receptor R2, SKR2, Activin receptor-like kinase 4, ALK-4
Genetic data
Gene code: HUGO code: ACVR1B
Protein Structure/Function
Protein type: Serine/Threonine receptor kinase
Domains: GS domain, TS domain, S/T domain
Taxa expressing:Homo sapiens; homologs: many metazoan phyla
Cell types:ubiquitous
Subcellular localization:Plasma membrane
Enzymatic Data
Catalytic activity:ATP + (receptor-protein) = ADP + (receptor-protein) phosphate
Cofactor(s):Magnesium or manganese
Medical/Biotechnological data
Diseases:Pancreatic Carcinoma

ACVR1B or ALK-4 acts as a transducer of Activin or activin like ligands (eg. Inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3.[1] ACVR1B also transduces signals of nodal, GDF-1, and Vg1; however, unlike activin, they require other coreceptor molecules such as the protein Cripto[2].

Symbol ACVR1B
Alt. Symbols ACVRLK4
Entrez 91
HUGO 172
OMIM 601300
RefSeq NM_020328
UniProt P36896
Other data
EC number
Locus Chr. 12 q13


  1. ^ Inman, GJ; Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (Jul 2002). "SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7". Mol Pharmacol. 62 (1). Entrez PubMed 12065756. Retrieved on 2006-07-05.
  2. ^ Harrison, CA; Gray PC, Koerber SC, Fischer W, Vale W (Jun 2003). "Identification of a functional binding site for activin on the type I receptor ALK4". J Biol Chem. 278 (23). Entrez PubMed 12665502. Retrieved on 2006-07-05.
  This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ACVR1B". A list of authors is available in Wikipedia.
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