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ADAMTS5



ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)
Identifiers
Symbol ADAMTS5
Entrez 11096
HUGO 221
OMIM 605007
RefSeq NM_007038
UniProt Q9UNA0
Other data
Locus Chr. 21 q22.1-q22

ADAMTS5 (aggrecanase) is an enzyme that destroys cartilage in mice. Its discovery may lead to progress in human arthritis research. This enzyme may also be involved in cartilage deterioration in humans. It has been isolated and identified by Australian scientists in Sydney. ADAMTS5 has been indicated as being important in early osteoarthritis.


v • d • e
Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteinADAMTS2 - ADAMTS13 - ADAMTS5 - ADAM17 - Alpha secretase
Matrix metalloproteinaseCollagenase - Gelatinase
OtherNeprilysin - Procollagen peptidase - Thermolysin - Pregnancy-associated plasma protein A - Bone morphogenetic protein 1 - Insulysin - Lysostaphin
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "ADAMTS5". A list of authors is available in Wikipedia.
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