To use all functions of this page, please activate cookies in your browser.
With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter.
- My watch list
- My saved searches
- My saved topics
- My newsletter
Acute phase protein
Acute-phase proteins are a class of proteins whose plasma concentrations increase (positive acute phase proteins) or decrease (negative acute phase proteins) in response to inflammation. This response is called the acute-phase reaction (also called acute phase response). In response to injury, local inflammatory cells (neutrophil granulocytes and macrophages) secrete a number of cytokines into the bloodstream, most notable of which are the interleukins IL-1, IL-6 and IL-8, and TNF-α.
Additional recommended knowledge
The liver responds by producing a large number of acute-phase reactants.
The notable are:
Serum albumin concentrations fall in acute disease states. For this reason albumin is sometimes referred to as a negative acute phase protein.
Measurement of acute phase proteins is a useful marker of inflammation in both medical and veterinary clinical pathology. It corellates with the erythrocyte sedimentation rate (ESR).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Acute_phase_protein". A list of authors is available in Wikipedia.|