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IUPAC name (5'R)-5'-hydroxy-2',5',7'-trimethyl-4'-spiro[cyclopropane-1,6'-indene]one
CAS number
PubChem 365701
Molecular formula C14H16O2
Molar mass 216.27564
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Acylfulvene is a cytotoxin that is related to illudin. Illudin itself can be extracted from the jack o'lantern mushroom (Omphalotus olearius). Acylfulvene is a compound that can be utilized towards the treatment of a wide assortment of cancers and tumors. It is thought that the acylfulvene compound cripples tumors by DNA alkylation (see DNA methylation), but the exact mechanism of their actions are not determined.

At present, paclitaxel (Taxol) is the drug of choice to contain tumors and cancers, but researchers claim that the efficacy of acylfulvene to fight various tumors is many times that of paclitaxel. The production and thus the use of acylfulvene is hampered by the fact that the extraction of illudin from mushrooms is difficult and also, at the present moment, acylfulvene is difficult to synthesize. Research on the biochemical interactions of acylfulvene is being conducted at the University of Missouri.[1]


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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Acylfulvene". A list of authors is available in Wikipedia.
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