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Chlortetracycline


Chlortetracycline
Systematic (IUPAC) name
(2Z,4S,4aS,5aS,6S,12aS)-2-(amino-hydroxy- methylidene)-7-chloro-4-dimethylamino-6,10,11,12a- tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene- 1,3,12-trione
Identifiers
CAS number	57-62-5
ATC code	D06AA02 A01AB21
PubChem	5280963
Chemical data
Formula	C₂₂H₂₃Cl N₂O₈
Mol. mass	478.879 g/mol
Pharmacokinetic data
Bioavailability	30%
Protein binding	50 to 55%
Metabolism	Hepatic (75%)
Half life	5.6 to 9 hours
Excretion	Renal and biliary
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral, IV, topical

Chlortetracycline (trade name Aureomycin®, Lederle) is a tetracycline antibiotic, and was the first tetracycline to be discovered. It was discovered in 1945 by Dr Benjamin Duggar in a soil sample from Sanborn Field at the University of Missouri, yielding an actinomycete, Streptomyces aureofaciens (hence the name Aureomycin). In veterinary medicine, it is commonly used to treat conjunctivitis in cats.^[1]

References

^ Merck Veterinary Manual.

v • d • e Stomatological preparations (A01)
Caries prophylactic agents	Sodium fluoride - Sodium monofluorophosphate - Olaflur - Stannous fluoride
Anti-infectives and antiseptics	Hydrogen peroxide - Chlorhexidine - Amphotericin B - Polynoxylin - Domiphen - Oxyquinoline - Neomycin - Miconazole - Natamycin - Hexetidine - Tetracycline - Benzoxonium chloride - Tibezonium iodide - Mepartricin - Metronidazole - Clotrimazole - Sodium perborate - Chlortetracycline - Doxycycline - Minocycline - Eugenol
Corticosteroids	Triamcinolone - Dexamethasone - Hydrocortisone
Other	Epinephrine/Adrenalone - Benzydamine - Acetylsalicylic acid - Amlexanox

v • d • e Antibiotics and chemotherapeutics for dermatological use (D06)
Antibiotics: tetracycline and derivatives	Demeclocycline - Chlortetracycline - Oxytetracycline - Tetracycline
Antibiotics: other	Fusidic acid - Chloramphenicol - Neomycin - Bacitracin - Gentamicin - Tyrothricin - Mupirocin - Virginiamycin - Rifaximin - Amikacin
Chemotherapeutics: sulfonamides	Silver sulfadiazine - Sulfathiazole - Mafenide - Sulfamethizole - Sulfanilamide - Sulfamerazine
Chemotherapeutics: antivirals	Idoxuridine - Tromantadine - Aciclovir - Podophyllotoxin - Inosine - Penciclovir - Lysozyme - Ibacitabine - Edoxudine - Imiquimod - Docosanol
Chemotherapeutics: other	Metronidazole

v • d • e Antibacterials for systemic use: tetracycline antibiotics (J01A)
Tetracyclines	Chlortetracycline • Clomocycline • Demeclocycline • Doxycycline • Lymecycline • Metacycline • Minocycline • Oxytetracycline • Penimepicycline • Rolitetracycline • Tetracycline
Glycylcyclines	Tigecycline