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Azole



An azole is a class of five-membered nitrogen heterocyclic ring compounds containing at least one other noncarbon atom, nitrogen, sulfur or oxygen. The parent compounds are aromatic and have two double bonds; there are successively reduced analogs (azolines and azolidines) with less. Names of azoles maintain the prefix upon reduction (such as pyrazoline, pyrazolidine), except for pyrrole, which has no -azole suffix and is reduced to pyrroline and pyrrolidine.

Additional recommended knowledge

Examples

The azoles include:

  • 1 nitrogen atom and 1 sulfur atom

A "dioxole" is a similar compound with two oxygen atoms in a five membered ring. Dioxolane is a derivative of dioxole.

Uses

Many azoles are used as antifungal drugs (azole antifungals), inhibiting the fungal enzyme 14α-demethylase which produces ergosterol.

References

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Azole". A list of authors is available in Wikipedia.
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