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BRENDA is the comprehensive enzyme information database. It is maintained and developed at the Institute of Biochemistry at the University of Cologne. Data on enzyme functions are extracted directly from the primary literature. Formal and consistency checks are done by computer programs and each data set is checked manually. The latest update was in January, 2004 which included:
Additional recommended knowledge
The database covers 40 data fields with information about nomenclature, reaction and specificity, enzyme structure, isolation/preparation, stability, literature references and cross references to sequence and 3D-structure data banks.
The resource is available free of charge for academic, non-profit users; commercial use requires a license. For use it requires registration by email. The database can be searched by EC number, enzyme name, organism, or an advanced search combining these terms.
As an example you can use the quick search to search for pyruvate dehydrogenase. This search gives several forms of the enzyme. If you click on pyruvate dehydrogenase (NADP+) it takes you to a page it gives you information on:
This page also shows all the organisms that contain this enzyme. If you wanted to determine the pyruvate dehydrogenase enzyme found in humans you can use the advance search using this query:
enzyme name = pyruvate dehydrogenase organism = homo sapiens
This query gives the result pyruvate dehydrogenase (lipoamide).
Other methods of searching include full text search, substructure search, TaxTree search (search an organism in taxonomy tree), search the EC tree and it is possible to do a sequence search.
BRENDA also links to other databases. Including KEGG which provides information about the pathway that the enzyme is involved in. It also links to gene ontology information through the GO website. There is also links to the literature through PubMed. Other databases that BRENDA link to include:
As of January 2007, the data repository was complemented by text-mining data in:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "BRENDA". A list of authors is available in Wikipedia.|