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The Barbier reaction is an organic reaction between an alkyl halide and a carbonyl group as an electrophilic substrate in the presence of aluminium, zinc, indium, tin or its salts. The reaction product is a secondary or tertiary alcohol. The reaction is similar to the Grignard reaction but the crucial difference is that the Barbier reaction is a One-pot synthesis whereas a Grignard reagent is prepared separately before addition of the carbonyl compound 1. Barbier reactions are nucleophilic addition reactions that take place with relatively inexpensive and water insensitive metals or metal compounds in contrast to Grignard reagents or organolithium reagents. For this reason it is possible in many cases to run the reaction in water which makes the procedure part of green chemistry. The Barbier reaction is named after Victor Grignard’s teacher Philippe Barbier.
Additional recommended knowledge
Examples of Barbier reactions are the reaction of propargylic bromide with butanal with zinc metal in water 2,
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Barbier_reaction". A list of authors is available in Wikipedia.|