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CARM1



coactivator-associated arginine methyltransferase 1
Identifiers
Symbol CARM1
Entrez 10498
HUGO 23393
OMIM 603934
RefSeq XM_032719
UniProt Q86X55
Other data
EC number 2.1.1.125
Locus Chr. 19 p13.2
coactivator associated arginine methyltransferase 1-like
Identifiers
Symbol CARM1L
Entrez 256280
HUGO 23392
RefSeq XM_171224
UniProt Q5SZY8
Other data
Locus Chr. 9 p24.2

CARM1 (coactivator-associated arginine methyltransferase 1) is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.[1] CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.[2] This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.[3][4]

See also

  • histone-arginine N-methyltransferase

References

  1. ^ Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999). "Regulation of transcription by a protein methyltransferase". Science 284 (5423): 2174–7. doi:10.1126/science.284.5423.2174. PMID 10381882.
  2. ^ Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M (2007). "Histone arginine methylation regulates pluripotency in the early mouse embryo". Nature 445 (7124): 214–8. doi:10.1038/nature05458. PMID 17215844.
  3. ^ Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L (2004). "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status". Cancer 101 (1): 83–9. doi:10.1002/cncr.20327. PMID 15221992.
  4. ^ Majumder S, Liu Y, Ford OH, Mohler JL, Whang YE (2006). "Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate 66 (12): 1292–301. doi:10.1002/pros.20438. PMID 16705743.



v • d • e
Transcription coregulators
CoactivatorsCARM1 - CRTC1 - CBP - NCOA1 (SRC-1) - NCOA2 (GRIP1/SRC-2/TIF2) - NCOA3 (AIB/SRC-3/TRAM-1) - NCOA4 - NCOA6 - NCOA7 - PPARGC1A - PPARGC1B - TGFB1I1
CorepressorsNCOR1 - NRIP1 - NCOR2 (SMRT) - PELP-1 - RCOR1 - Rb - SIN3A- SIN3B - Tripartite motif-containing (TRIM24, TRIM28)
ATP-dependent remodeling factorsChromatin Structure Remodeling (RSC) Complex - SWI/SNF
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CARM1". A list of authors is available in Wikipedia.
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