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Cilastatin



Cilastatin
Systematic (IUPAC) name
(Z)-7-[(2S)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-{[(1S)-
2,2-dimethylcyclopropanecarbonyl]amino}hept-2-enoic acid
Identifiers
CAS number 82009-34-5
ATC code  ?
PubChem 5280454
DrugBank EXPT00918
Chemical data
Formula C16H26N2O5S 
Mol. mass 358.454 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase. [1]

Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin in and of itself does not have any antibacterial activity.

References

  1. ^ Keynan S, Hooper NM, Felici A, Amicosante G, Turner AJ (1995). "The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA". Antimicrob. Agents Chemother. 39 (7): 1629-31. PMID 7492120.

See also
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cilastatin". A list of authors is available in Wikipedia.
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