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Additional recommended knowledge
Dehydropeptidase is found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin is therefore combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. However, cilastatin in and of itself does not have any antibacterial activity.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Cilastatin". A list of authors is available in Wikipedia.|