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Claudins are small (20-27 kilodalton (kDa)) transmembrane proteins which are found in many organisms, ranging from nematodes to human beings, and are very similar in their structure, although this conservation is not observed on the genetic level. Claudins span the cellular membrane 4 times, with the N-terminal end and the C-terminal end both located in the cytoplasm, and two extracellular loops which show the highest degree of conservation. The first extracellular loop consists on average of 53 amino acids and the second one, being slightly smaller, of 24 amino acids. The N-terminal end is usually very short (4-10 amino acids), the C-terminal end varies in length from 21 to 63 and is necessary for the localisation of these proteins in the tight junctions . It is suspected that the cysteines of individual or separate claudins form disulfide bonds. All human claudins (with the exception of Claudin 12) have domains that let them bind to PDZ domains of scaffold proteins.
Claudins were first named in 1998 by the Japanese researchers Mikio Furuse and Shoichiro Tsukita at the Kyoto University . The name claudin comes from Latin word claudere ("to close"), suggesting the barrier role of these proteins.
In humans, 24 members of the family have been described.
Categories: Cell adhesion proteins | Structural proteins
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Claudin". A list of authors is available in Wikipedia.|