My watch list
my.chemeurope.com  
Login  

Clidinium



Clidinium
Systematic (IUPAC) name
(1-methyl-1-azoniabicyclo[2.2.2]octan-8-yl) 2-hydroxy-2,2-di(phenyl)acetate
Identifiers
CAS number 7020-55-5
3485-62-9 (bromide salt)
ATC code A03CA02
PubChem 2784
DrugBank APRD00737
Chemical data
Formula C22H26NO3+
Mol. mass 352.447 g/mol
Pharmacokinetic data
Bioavailability Low
Metabolism  ?
Half life  ?
Excretion Renal and biliary
Therapeutic considerations
Pregnancy cat.

?

Legal status

-only(US)

Routes Oral

Clidinium (generally found as the bromide salt, clidinium bromide) is an anticholinergic drug. It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. It is commonly prescribed in combination with chlordiazepoxide using the brand name Librax.

Additional recommended knowledge

Clidinium is an effective anticholinergic agent with activity approximating that of atropine sulfate against spasms induced by acetylcholine in isolated intestinal strips. On oral administration in mice it proved an effective antisialagogue in preventing salivation induced by pilocarpine. Spontaneous intestinal motility in both rats and dogs is reduced following oral dosing with 0.1 to 0.25 mg/kg. Potent cholinergic ganglionic blocking effects (vagal) are produced with intravenous usage in anesthetized dogs.

Oral doses of 23 mg/kg to dogs produced signs of nasal dryness and slight pupillary dilation. In two other species, monkeys and rabbits, doses of 5 mg/kg, po, given three times daily for 5 days did not produce apparent secretory or visual changes.

Toxicity

The oral LD50 of a single dose of clidinium bromide is 860 + 57 mg/kg, as determined in mice observed over a period of 5 days following dosage.

 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Clidinium". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE