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Systematic (IUPAC) name
CAS number 14860-49-2
ATC code R05DB03
PubChem 26937
Chemical data
Formula C14H22ClNO 
Mol. mass 255.783 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes  ?

Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.

Side effects and withdrawal

It was recently determined to cause cardiac arrhythmia in some patients.

Recent studies have indicated that clobutinol has the potential to prolong the QT interval.[1][2].

Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007[3] [4][5].

See also


  1. ^ Bellocq C, Wilders R, Schott JJ, et al (2004). "A common antitussive drug, clobutinol, precipitates the long QT syndrome 2". Mol. Pharmacol. 66 (5): 1093-102. doi:10.1124/mol.104.001065. PMID 15280442.
  2. ^ Expert statement on BfArM website: [1]. Retrieved 2007-SEP-01.
  3. ^ Yahoo! News: Bundesinstitut ruft Hustenmittel zurück [in German]. Retrieved 2007-AUG-31.
  4. ^ Bundesinstitut verbietet Hustenmittel Clobutinol [in German]. Retrieved 2007-AUG-31.
  5. ^ Company Website:Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications [English]. Retrieved 2007-Sep-01.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Clobutinol". A list of authors is available in Wikipedia.
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