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The Dötz reaction is the chemical reaction of an aromatic or vinylic alkoxy pentacarbonyl chromium carbene complex with an alkyne and carbon monoxide to give a Cr(CO)3-coordinated substituted phenol. Several reviews have been published. It is named after the German chemist Karl Heinz Dötz (b. 1943).
Additional recommended knowledge
The position of the substituents is highly predictable with the largest alkyne substituent (RL) neighboring the phenol and the smallest alkyne substituent (RS) neighboring the methoxy group.Hence, this reaction is more useful for terminal alkynes than internal alkynes.
Since this reaction can quickly generate complex phenolic compounds, the Dötz reaction has been used most often in the synthesis of natural products.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dötz_reaction". A list of authors is available in Wikipedia.|