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A transpeptidase (EC is a bacterial enzyme which cross-links the peptidoglycan chains to form rigid cell walls. This enzyme is also known by several other names including DD-peptidase, DD-transpeptidase, D-alanyl-D-alanine carboxypeptidase and serine-type D-Ala-D-Ala carboxypeptidase.[1]

The protein transpeptidase is also known as Novel penicillin binding protein, which is necessary for cell wall peptidoglycan formation and is inhibited by penicillin.

The antibiotic penicillin binds to and inhibits the activity of the transpeptidase enzyme. Because of the interaction between penicillin and transpeptidase, this enzyme is also known as "penicillin binding protein."


  1. ^ E.C. Serine-type D-Ala-D-Ala carboxypeptidase. Enzyme Structures Database. Retrieved on February 26, 2006.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "DD-transpeptidase". A list of authors is available in Wikipedia.
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