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Dale's Principle (or Dale's Law) was postulated by the English neuroscientist Henry Hallett Dale and it states that, although different neurotransmitters can be produced at different synapses within the brain, individual neurons are capable of releasing only one neurotransmitter from its axonal terminal. Although Dale's Principle has been shown to be false in many cases, it none the less remains correct for the vast majority of neurons forming the human brain.
Additional recommended knowledge
Exceptions are composed of neuron types releasing two or more neurotransmitters at the same time and include:
Some types of neurons are also known to co-release classical neurotransmitters with a signaling peptide hormone. Examples include:
Dale stated that a neurotransmitter must:
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dale's_principle". A list of authors is available in Wikipedia.|