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Datura stramonium, known by the common names Jimson Weed, Gypsum Weed, Ditch Weed, Stink Weed, Loco Weed,Korean Morning Glory, Jamestown Weed, Thorn Apple, Angel's Trumpet, Devil's Trumpet, Devil's Snare, Devil's Seed, Mad Hatter, Crazy Tea, Malpitte, The Devil's Balls and, along with datura metel, Zombie Cucumber is a common weed in the Nightshade Family. It contains tropane alkaloids that are sometimes used as a hallucinogen. The active ingredients are atropine, hyoscyamine and scopolamine which are classified as deliriants, or anticholinergics. Due to extremely high risk of overdose, many deaths and hospitalizations are reported from recreational use.
Datura stramonium also called dhatura is an erect annual plant, on average 30 to 150 cm (1-5 feet) tall with erect, forking and purple stems. The leaves are large, 7 to 20 cm (3-8 in) long and have irregular teeth similar to those of oak leaves. The flowers are one of the most distinctive characteristics of Datura stramonium: they are trumpet-shaped, white to purple, and 2-7 in. (5-12.5 cm) long. The flowers, with the same fragrance as Mirabilis jalapa, open and close at irregular intervals during the evening, earning the plant the nickname Moonflower. The fruit are walnut-sized, egg-shaped, and covered in prickles, they split into four chambers, each with a few kidney-shaped seeds. All parts of the plant emit a foul odor when crushed or bruised.
Additional recommended knowledge
The genus was derived from "dhatura", an ancient Hindu word for the plant. The specific name is New Latin word meaning "thornapple". Stramonium is originally from Greek, strychnos (nightshade) and manikos (mad). 
There is a mnemonic device for the physiological effects of datura/atropine intoxication: "blind as a bat, mad as a hatter, red as a beet, hot as hell, dry as a bone, the bowel and bladder lose their tone, and the heart runs alone." Another rhyme describing its effects is, "Can't see, can't spit, can't pee, can't shit." Regarding Datura, among the Navajo is the folk admonition, 'Eat a little, and go to sleep. Eat some more, and have a dream. Eat some more, and don't wake up.' The actual effects are reported to be: cycloplegia and mydriasis (extreme dilation of the pupil), flushed, warm and dry skin, dry mouth, urinary retention and ileus (slowing or stopping of intestinal movement), rapid heart beat, hypertension or hypotension, and choreoathetosis/jerky movements. In case of overdose the effects are hyperthermia, coma, respiratory arrest, and seizures. The vast majority of atropine-poisoning cases are accompanied by delirium with visual and auditory hallucinations.
The effects of Datura have been described as a living dream: consciousness falls in and out, people who don't exist or are miles away are conversed with, etc. The effects can last for days. Tropane alkaloids are some of the few substances which cause true hallucinations which cannot be distinguished from reality. It may be described as a "real" trance when a user under the effect can be awake but completely disconnected from his immediate environment. In this case, the user would ignore most stimuli and respond to unreal ones. This is unlike psilocybin or LSD, which only cause sensory distortions.
The doses that cause noticeable effects, and the doses that can kill are very close with datura. This makes overdosing on Datura stramonium very easy. This can be fatal; it can cause fevers in the 105-110 (40-43°C) range which is a range that can kill brain cells, and lead to brain damage. There have been many instances of teenagers looking for a cheap high poisoning themselves to death on datura. If someone overdoses on datura it is advised to induce vomiting, to wash out his or her stomach, and to get the person hospitalized immediately.
If taken recreationally and the user does not notice any conscious effects, most people redose thinking it's not working, which is why overdoses are so common. The user doesn't realize that he or she was hallucinating. Some users have reported seeing an array of people from their lives. A few anecdotal reports also mention the user's perception of "phantom cigarettes"; the person believes that he or she is smoking a cigarette only to find that it has disappeared later, thus realizing that it never existed. There have been reports of the user interacting with other unreal objects also, such as looking down and seeing a cigarette lighter in one's hand then dropping it, and after a minute or two of searching, the user often realizes that this lighter or any other unreal object never existed. Returning to "reality" from datura-induced hallucinations is often coupled with momentary disorientation. At the peak of such experiences users often enter a true psychotomimetic state, in which they "lose touch with reality" altogether; at this point, many find it difficult or impossible to communicate with others.
A majority of users who have written reports on experiences with this drug have described those experiences as unpleasant and often terrifying. This is possibly due to their having taken excessive doses. The powerful effects of Datura continue until the body metabolizes the tropane alkaloids.
Scopolamine is the primary hallucinogen in Datura wrightii from California and other Daturas. Scopolamine can be slowly and erratically absorbed into the brain. In most people, scopolamine reaches the brain within an hour or so after ingestion and causes visual and auditory hallucinations. In about 25% of people, scopolamine is very slowly absorbed into the brain, taking up to 13 hours to enter the brain. These are the people who are at the highest risk of overdosing. They become impatient waiting for their recreational high and take more of the plant extract.
Datura stramonium is native to either India or Central America. It was used as a mystical sacrament in both possible places of origin. The Native Americans have used this plant in sacred ceremonies. In some tribes datura was involved in the ceremonies of manhood. The sadhus of Hinduism also used datura as a spiritual tool, smoking it with cannabis in their traditional chillums.
In the United States it is called Jimson weed, Gypsum weed, Angel Trumpet, Hells Bells or more rarely Jamestown Weed; it got this name from the town of Jamestown, Virginia, where British soldiers were secretly or accidentally drugged with it, while attempting to suppress Bacon's Rebellion. They spent several days chasing feathers, making monkey faces, generally acting like lunatics, and indeed failed at their mission:
Some of the soldiers sent thither to quell the rebellion of Bacon (1676); and some of them ate plentifully of it, the effect of which was a very pleasant comedy, for they turned natural fools upon it for several days: one would blow up a feather in the air; another would dart straws at it with much fury; and another, stark naked, was sitting up in a corner like a monkey, grinning and making mows [grimaces] at them; a fourth would fondly kiss and paw his companions, and sneer in their faces with a countenance more antic than any in a Dutch droll.
There was a time when stramonium, a drug obtained from the leaves and seeds of Datura stramonium, was used medicinally (Herbalgram). The alkaloid was known as daturine. From the seeds was made extractum stramonii. The tinctura stramonii was made from the leaves. Stramonium was used to relax the smooth muscle of the bronchial tubes, and thus it was used to treat an asthmatic's bronchial spasm. Cigarettes were made of stramonium leaves which could be smoked; or the tincture was taken internally. Frequently the leaves were powdered together with equal quantities of the leaves of Cannabis and Lobelia mixed with potassium nitrate, and were burned in an open dish. The preparation was reported to give off dense fumes which afforded great relief to the asthmatic paroxysm. Around the turn of the century numerous patent "cures" for asthma contained these ingredients in varying proportions. Daturine was also used to treat acute mania as hyoscyamine was said to produce sleep. Because of the dangers of tropane poisoning, datura is not used medicinally today, and the Food and Drug Administration (FDA) has determined it to be unfit for human consumption. However, atropine, scopolamine and hyoscyamine are FDA approved drugs that are used everyday for a variety of conditions.
The antidote of choice for overdose or poisoning is physostigmine. 
This article incorporates text from the Encyclopædia Britannica Eleventh Edition, a publication now in the public domain.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Datura_stramonium". A list of authors is available in Wikipedia.|