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Dexrazoxane hydrochloride (Zinecard®, Pharmacia) is a medication used to protect the heart against the cardiotoxic side effects of anthracycline chemotherapy. As a derivative of EDTA, dexrazoxane chelates iron, but the precise mechanism by which it protects the heart is not known.
Additional recommended knowledge
It is also used in oncology as an intravenously delivered antidote following extravasation--an adverse event in which chemotherapies containing anthracylines leak out of the blood vessel and necrotize the surrounding tissue.
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dexrazoxane". A list of authors is available in Wikipedia.|