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Diatrizoic acid



Diatrizoic acid
IUPAC name 3,5-diacetamido-2,4,6-triiodo-benzoic acid
Identifiers
CAS number
SMILES CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)NC(=O)C)I
Properties
Molecular formula C11H9I3N2O4
Molar mass 613.9 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Diatrizoic acid (or its anionic form, Diatrizoate), also known as amidotrizoic acid, or 3,5-Diacetamido-2,4,6-triiodobenzoic acid, is an iodine-containing radiocontrast agent. It is also used to kill tapeworms.

Additional recommended knowledge

Diatrizoate is considered a high-osmolality contrast agent. Its osmolality ranges from approximately 1500 mOsm/kg (50% solution)[1] to over 2000 mOsm/kg (76% solution).[2]

Administration

  • It is given intravenously (under brand name Hypaque®, GE Healthcare) to enhance contrast in computed tomography, to image the kidneys and related structures, and to image blood vessels.
  • It is given orally or by enema (Gastrografin®, Gastrovist®, Gastrovision®, MD-Gastroview®) to image the gastrointestinal tract.
  • It is given by Foley catheter (Cystografin®) to image the urinary tract

Contraindications

A history of sensitivity to iodine is not a contraindication to using diatrizoate, although it suggests caution in use of the agent.

References

  1. ^ Amersham Health (April 2006). Hypaque sodium (Diatrizoate Sodium) injection, solution. Product label. DailyMed. U.S. National Library of Medicine. Retrieved on 2007-03-29.
  2. ^ Amersham Health (April 2006). Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label. DailyMed. U.S. National Library of Medicine. Retrieved on 2007-03-29.
 
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Diatrizoic_acid". A list of authors is available in Wikipedia.
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