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An E-box is a DNA sequence which usually lies upstream of a gene in a promoter region. The consensus sequence for the E-box element is CANNTG, with a palindromic canonical sequence of CACGTG. Transcription factors containing the basic-helix-loop-helix protein structural motif typically bind to E-boxes or related variant sequences and enhance transcription of the downstream gene.
Additional recommended knowledge
Proteins that interact with E-boxes
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "E-box". A list of authors is available in Wikipedia.|