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IUPAC name 8-Methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylic acid
Other names Anhydroecgonine
CAS number 484-93-5
PubChem 101709
Molecular formula C9H13NO2
Molar mass 167.205 g/mol
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)

Infobox disclaimer and references

Ecgonidine (anhydroecgonine) is an alkaloid related to ecgonine and cocaine.

Methylecgonidine is produced by pyrolysis in the process of smoking crack cocaine, and then subsequently metabolised to ecgonidine, and so these two compounds can be tested for as a specific biomarker for crack cocaine use.[1] Ecgonidine is formed as a metabolite of methylecgonidine, and so the relative concentrations of the two compounds can be used to gauge how recently crack cocaine was smoked; if levels of methylecgonidine are higher then the drug was smoked recently, however after a longer time period mainly ecgonidine will be present.[2] Ecgonidine has a half-life in the body of around 94-137 minutes, and so can be used to detect use of crack cocaine up to 8-10 hours after the drug is consumed.


  1. ^ Scheidweiler KB, Shojaie J, Plessinger MA, Wood RW, Kwong TC. Stability of methylecgonidine and ecgonidine in sheep plasma in vitro. Clinical Chemistry. 2000 Nov;46(11):1787-95.
  2. ^ Paul BD, McWhorter LK, Smith ML. Electron ionization mass fragmentometric detection of urinary ecgonidine, a hydrolytic product of methylecgonidine, as an indicator of smoking cocaine. Journal of Mass Spectrometry. 1999 Jun;34(6):651-60.
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Ecgonidine". A list of authors is available in Wikipedia.
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