My watch list  

Epoxide hydrolase

epoxide hydrolase 1, microsomal (xenobiotic)
Symbol EPHX1
Alt. Symbols EPHX
Entrez 2052
HUGO 3401
OMIM 132810
RefSeq NM_000120
UniProt P07099
Other data
EC number
Locus Chr. 1 q42.1
epoxide hydrolase 2, cytoplasmic
Symbol EPHX2
Entrez 2053
HUGO 3402
OMIM 132811
RefSeq NM_001979
UniProt P34913
Other data
Locus Chr. 8 p21

Epoxide hydrolase (also known as Epoxide hydratase) functions in detoxication during drug metabolism. It converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body.

Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Epoxide_hydrolase". A list of authors is available in Wikipedia.
Your browser is not current. Microsoft Internet Explorer 6.0 does not support some functions on Chemie.DE