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Activation of the Rho family of small Ras-related GTPases and their downstream intermediates results in the construction of actin fibers (Ohta et al, 1999). Growth factors bind to receptor tyrosine kinases resulting in the polymerization of actin filaments, which cross-linked, make up the supporting cytoskeletal elements of filopodia. Rho activity also results in the activation of the phosphorylation of the ezrin-moesin-radixin group promoting the binding of actin filaments to the filopodia membrane (Ohta et al, 1999).
To close a wound in vertebrates, growth factors stimulate the formation of filopodia in fibroblasts to direct fibroblast division and close the wound (Bentley et al, 1986). In developing neurons, filopodia extend from the growth cone at the leading edge. In neurons deprived of filopodia by the removal of actin filaments, growth cone extension continues as normal but direction of growth is disrupted and highly irregular (Bentley et al, 1986).
|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Filopodia". A list of authors is available in Wikipedia.|