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Frederic M. Richards
Frederic Middlebrook Richards (born c. 1925) or commonly referred to as Fred Richards is Sterling Professor Emeritus of Molecular Biophysics and Biochemistry at Yale University
Additional recommended knowledge
Richards most notable accomplishment was when through a simple experiment, he changed the current view that proteins were colloids into the modern view that proteins are well-ordered structures. The experiment was performed on Dec 7, 1957 involving the protein Ribonuclease A (RNase A). Using a particular protease, RNase A breaks into two parts called: RNase S and the S-protein. Initially, no one could purify the two components without. Richards found that when separated RNase S and the S-peptide had no RNase activity, but when recombined in the test tube the RNase activity is restored. The conclusion from this experiment shows that proteins maintain order and has thus influenced the idea ligands binding to proteins which used by all pharmicutical companies to design drugs. This result was two years before the protein structure of myoglobin confirmed this.
Along with Hal Wyckoff, the effort to solve the RNase S structure was spearheaded by Fred Richards. RNase S became the third protein structure determined by X-ray diffraction of crystals after myoglobin and lysozyme.
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|This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Frederic_M._Richards". A list of authors is available in Wikipedia.|