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GMP phosphodiesterase, delta subunit

Membrane-bound ADP ribosylation factor-like protein 2 (ARL2 mouse, red), complex with phosphodiesterase delta (yellow) (1ksg) Blue dots show hydrocarbon boundary of the lipid bilayer
GMP-PDE, delta subunit
Symbol GMP_PDE_delta
Pfam PF05351
InterPro IPR008015
SCOP 1ksj
OPM protein 1ksg
Available PDB structures:

1kshB:7-150 1ksgB:7-150 1ksjB:7-150

GMP-PDE delta subunit was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transport[1].

Human proteins containing this domain

PDE6D; UNC119;


  1. ^ Wittinghofer A, Renault L, Hanzal-bayer M, Roversi P, Hillig RC (2002). "The complex of Arl2-GTP and PDE delta: from structure to function". EMBO J. 21 (9): 2095-2106. PMID 11980706.

This article includes text from the public domain Pfam and InterPro IPR008015

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "GMP_phosphodiesterase,_delta_subunit". A list of authors is available in Wikipedia.
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