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Systematic (IUPAC) name
methyl (E)-7-[(1R,2S,3R)-3-hydroxy-2-
CAS number 64318-79-2
ATC code G02AD03
PubChem 5282237
Chemical data
Formula C23H38O5 
Mol. mass 394.545 g/mol
SMILES search in eMolecules, PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.


Legal status
Routes Pessary

Gemeprost (16, 16-dimethyl-trans-delta2 PGE1 methyl ester) is an analogue of prostaglandin E1.

Clinical use

In pessary form as the second drug in medical abortion regimen in the UK and Sweden. Gemeprost softens and dilates the cervix and stimulates the uterus to contract.

Side effects

Vaginal bleeding, cramps, nausea, vomiting, loose stools or diarrhea, headache, muscle weakness; dizziness; flushing; chills; backache; dyspnoea; chest pain; palpitations and mild pyrexia. Rare: Uterine rupture, severe hypotension, coronary spasms with subsequent myocardial infarctions.

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Gemeprost". A list of authors is available in Wikipedia.
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