• microtubule motor activity • MHC class I receptor activity • MHC class II receptor activity
Cellular Component:
• axonemal dynein complex • integral to plasma membrane • membrane • integral to membrane • MHC class I protein complex
Biological Process:
• ciliary or flagellar motility • antigen processing and presentation of peptide antigen via MHC class I • immune response • antigen processing and presentation
RNA expression pattern
More reference expression data
Orthologs
Human
Mouse
Entrez
3107
667977
Ensembl
ENSG00000204525
na
Uniprot
P10321
na
Refseq
XM_001131707 (mRNA) XP_001131707 (protein)
XM_001003863 (mRNA) XP_001003863 (protein)
Location
Chr 6: 31.34 - 31.35 Mb
na
Pubmed search
[1]
[2]
HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.
HLA-C is a locus on chromosome 6 that encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.
Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
Cw*0707 to *0711, *0713, *0715, and *0717 to *0729
Cw*08
Cw8 Serotype: Cw*0801, *0802 and *0803
Cw*805 to *0812
Cw*1202 to *1215
Cw*1402 to *1405
Cw*1501 to *1511
Cw*1601 to *1606
Cw*1701 to *1703
Cw*1801 and *1802
Common Haplotype
Cw4-B35 (Western Africa to Native Americans)
Cw7-B7 (Western Eurasia, South Africa)
Cw7-B8 (Western Eurasia)
Cw1-B46 (China, Indochina)
Cw5-B44 (Western Eurasia)
References
^ Ríos A, Rodríguez J, Moya M, Galindo P, Canteras M, Alvarez M, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg141 (2): 123-8. PMID 16490887.
^ Montes-Ares O, Moya-Quiles M, Montes-Casado M, Guerra-Pérez N, Campillo J, González C, López-Bermejo A, Tamayo M, Majado M, Parrado A, Muro M, Marín L, Alvarez-López M (2006). "Human leucocyte antigen-C in B chronic lymphocytic leukaemia.". Br J Haematol135 (4): 517-9. PMID 17054674.
Further reading
Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep.2 (7): 580-5. doi:10.1093/embo-reports/kve141. PMID 11463741.
Greenway AL, Holloway G, McPhee DA, et al. (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.". J. Biosci.28 (3): 323-35. PMID 12734410.
Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris)19 (1): 100-6. PMID 12836198.
Leavitt SA, SchOn A, Klein JC, et al. (2004). "Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.". Curr. Protein Pept. Sci.5 (1): 1-8. PMID 14965316.
Tolstrup M, Ostergaard L, Laursen AL, et al. (2004). "HIV/SIV escape from immune surveillance: focus on Nef.". Curr. HIV Res.2 (2): 141-51. PMID 15078178.
Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res.3 (1): 87-94. PMID 15638726.
Anderson JL, Hope TJ (2005). "HIV accessory proteins and surviving the host cell.". Current HIV/AIDS reports1 (1): 47-53. PMID 16091223.